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Ectopic tissue

MedGen UID:
40280
•Concept ID:
C0008519
•
Pathologic Function
Synonym: Heterotopia
SNOMED CT: Heterotopic tissue (128490007); Heterotopia (128490007); Choristoma (417338002); Heterotopic structure, either congenital or acquired (128490007); Ectopic tissue (719446000); Aberrant tissue (719446000); Ectopia (719446000)

Definition

Proliferation of normal tissue in an anatomic site in which this particular type of tissue is not normally present. [from NCI]

Professional guidelines

PubMed

Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Safety of treatment with DLA-identical or unrelated mesenchymal stromal cells in DLA-identical canine bone marrow transplantation.
Kornblit B, Leisenring WM, Santos EB, Storb R, Sandmaier BM
Chimerism 2013 Jul-Sep;4(3):95-101. Epub 2013 May 29 doi: 10.4161/chim.25110. PMID: 23723082Free PMC Article
Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages.
Ringden O, Le Blanc K
Best Pract Res Clin Haematol 2011 Mar;24(1):65-72. Epub 2011 Feb 25 doi: 10.1016/j.beha.2011.01.003. PMID: 21396594

Recent clinical studies

Etiology

Meckel's diverticulectomy: a multi-centre 19-year retrospective study.
Tree K, Kotecha K, Reeves J, Aitchison L, Noeline Chui J, Gill AJ, Mittal A, Samra JS
ANZ J Surg 2023 May;93(5):1280-1286. Epub 2023 Feb 23 doi: 10.1111/ans.18351. PMID: 36821518
Ectopic thyroid in EBUS: experience from a quality assurance programme.
Vuorisalo A, Tommola E, Eloranta P, Vanhelo T, Paavonen T, Kholová I
APMIS 2023 May;131(5):217-225. Epub 2023 Mar 3 doi: 10.1111/apm.13303. PMID: 36809572
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target.
Agostinis C, Balduit A, Mangogna A, Zito G, Romano F, Ricci G, Kishore U, Bulla R
Front Immunol 2020;11:599117. Epub 2021 Jan 11 doi: 10.3389/fimmu.2020.599117. PMID: 33505394Free PMC Article
Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis.
Parkin KL, Fazleabas AT
Am J Reprod Immunol 2016 Mar;75(3):411-7. Epub 2016 Jan 19 doi: 10.1111/aji.12487. PMID: 26782366Free PMC Article

Diagnosis

Biomarkers of endometriosis.
Pant A, Moar K, K Arora T, Maurya PK
Clin Chim Acta 2023 Sep 1;549:117563. Epub 2023 Sep 20 doi: 10.1016/j.cca.2023.117563. PMID: 37739024
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
The Origin and Pathogenesis of Endometriosis.
Wang Y, Nicholes K, Shih IM
Annu Rev Pathol 2020 Jan 24;15:71-95. Epub 2019 Sep 3 doi: 10.1146/annurev-pathmechdis-012419-032654. PMID: 31479615Free PMC Article
Review of Endometriosis Diagnosis through Advances in Biomedical Engineering.
Shah R, Jagani RP
Crit Rev Biomed Eng 2018;46(3):277-288. doi: 10.1615/CritRevBiomedEng.2018027414. PMID: 30311558
Benign vulvar tumors.
Hood AF, Lumadue J
Dermatol Clin 1992 Apr;10(2):371-85. PMID: 1318812

Therapy

INSPECT: A Retrospective Study to Evaluate Long-term Effectiveness and Safety of Darvadstrocel in Patients With Perianal Fistulizing Crohn's Disease Treated in the ADMIRE-CD Trial.
Panés J, Bouma G, Ferrante M, Kucharzik T, Nachury M, de la Portilla de Juan F, Reinisch W, Selvaggi F, Tschmelitsch J, Brett NR, Ladouceur M, Binek M, Hantsbarger G, Campbell-Hill S, Karki C, Buskens C
Inflamm Bowel Dis 2022 Nov 2;28(11):1737-1745. doi: 10.1093/ibd/izab361. PMID: 35099555Free PMC Article
Immune Regulation of the Metastatic Process: Implications for Therapy.
de Mingo Pulido A, Ruffell B
Adv Cancer Res 2016;132:139-63. Epub 2016 Jun 17 doi: 10.1016/bs.acr.2016.05.004. PMID: 27613132Free PMC Article
Insurance approval of mesenchymal stem cell for acute GVHD in Japan: need of follow up for some remaining concerns.
Miyamura K
Int J Hematol 2016 Feb;103(2):155-64. Epub 2016 Jan 12 doi: 10.1007/s12185-015-1930-x. PMID: 26759322
Medical treatments for endometriosis.
Kappou D, Matalliotakis M, Matalliotakis I
Minerva Ginecol 2010 Oct;62(5):415-32. PMID: 20938427
Gastrointestinal duplications: Experience in seven children and a review of the literature.
Olajide AR, Yisau AA, Abdulraseed NA, Kashim IO, Olaniyi AJ, Morohunfade AO
Saudi J Gastroenterol 2010 Apr-Jun;16(2):105-9. doi: 10.4103/1319-3767.61237. PMID: 20339180Free PMC Article

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Review of Endometriosis Diagnosis through Advances in Biomedical Engineering.
Shah R, Jagani RP
Crit Rev Biomed Eng 2018;46(3):277-288. doi: 10.1615/CritRevBiomedEng.2018027414. PMID: 30311558
Insurance approval of mesenchymal stem cell for acute GVHD in Japan: need of follow up for some remaining concerns.
Miyamura K
Int J Hematol 2016 Feb;103(2):155-64. Epub 2016 Jan 12 doi: 10.1007/s12185-015-1930-x. PMID: 26759322
Gastrointestinal tract duplications in children.
Okur MH, Arslan MS, Arslan S, Aydogdu B, Türkçü G, Goya C, Uygun I, Cigdem MK, Önen A, Otcu S
Eur Rev Med Pharmacol Sci 2014;18(10):1507-12. PMID: 24899610
Gastrointestinal duplications: Experience in seven children and a review of the literature.
Olajide AR, Yisau AA, Abdulraseed NA, Kashim IO, Olaniyi AJ, Morohunfade AO
Saudi J Gastroenterol 2010 Apr-Jun;16(2):105-9. doi: 10.4103/1319-3767.61237. PMID: 20339180Free PMC Article

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Current concepts of ectopic nodal inclusions with special emphasis on nodal nevi.
Müller CSL, Müller SG, Vogt T, Pföhler C
J Dtsch Dermatol Ges 2021 Aug;19(8):1145-1157. doi: 10.1111/ddg.14521. PMID: 34390159
INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1-Deficient Mice.
Cheng Z, O'Brien K, Howe J, Sullivan C, Schrier D, Lynch A, Jungles S, Sabbagh Y, Thompson D
J Bone Miner Res 2021 Aug;36(8):1594-1604. Epub 2021 May 5 doi: 10.1002/jbmr.4315. PMID: 33900645
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target.
Agostinis C, Balduit A, Mangogna A, Zito G, Romano F, Ricci G, Kishore U, Bulla R
Front Immunol 2020;11:599117. Epub 2021 Jan 11 doi: 10.3389/fimmu.2020.599117. PMID: 33505394Free PMC Article
Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity.
Lim JP, Chong MS, Tay L, Yang YX, Leung BP, Yeo A, Yew S, Tan CH, Lim WS
Arch Gerontol Geriatr 2019 Mar-Apr;81:1-7. Epub 2018 Nov 13 doi: 10.1016/j.archger.2018.11.006. PMID: 30469093

Recent systematic reviews

Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.
Hansen CC, Søreide K
Medicine (Baltimore) 2018 Aug;97(35):e12154. doi: 10.1097/MD.0000000000012154. PMID: 30170459Free PMC Article
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z
Am J Reprod Immunol 2017 Apr;77(4) Epub 2017 Jan 25 doi: 10.1111/aji.12622. PMID: 28120482

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